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Partners Online Second Opinions

For those with complex medical questions or concerns, looking for answers or alternatives, or simply peace of mind – we are here to help.

Partners Online Second Opinions has provided thousands of patients and physicians remote access to the many specialists affiliated with Partners HealthCare, a Harvard Medical School-affiliated healthcare delivery system, based in Boston, Massachusetts.

The Partners HealthCare network includes top hospitals in the United States, including Massachusetts General Hospital, Brigham and Women’s Hospital, Dana Farber Cancer Institute, and Spaulding Rehabilitation Hospital. Many of our specialists are world-renowned experts in their field, and are available to review medical history and related materials, and provide you with a written consultation report.

When you are faced with decisions regarding a new diagnosis or treatment plan, having another expert opinion is the first step towards getting the care you need.

For 200 years, patients have been traveling to Boston to get some of the best care in the world. Now you can access this expertise from the comfort of your home.


Featured Specialist
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Ketih Ligon, MD


Our work focuses most generally on the types of brain tumors called gliomas that affect adults and children. Several of our projects have identified the transcription factor networks that control normal and tumorigenic neural stem/progenitor cells and applied these findings to improve diagnosis and treatment of brain tumor patients. Our group uses a variety of approaches including primary human tissue and cancer "stem" cell models, mouse genetics, integrative genomics, translational human research, and molecular neuropathology. A key area of expertise in my lab is the development of sophisticated human patient derived cell lines (PDCLs) and patient derived xenografts (PDX) which serve as "patient avatars" or model systems. These models allow us to more accurately study brain tumors outside of patients and develop new treatments in collaboration with pharmaceutical partners and academic institutions. My lab is involved in several national clinical trials of brain tumors and translational research studies to identify improved genetic and pathologic markers of human brain tumors. Using integrative genomics, preclinical modeling and clinical outcomes data analysis these studies have lead to planning and performance of more ‘personalized’ clinical trials through collaboration with the broader neurooncology community at the DFCI, BWH and CHB. As a member of the Center for Molecular Oncologic Pathology at the DFCI/BWH, our lab also seeks to develop improved techniques for evaluation of human cancer pathways that can be directly translated into clinical diagnostic practice at the BWH clinical labs. Our lab also aids the broader neurooncology community by directing the Neuroonocology Program Tissue Bank and the Living Tissue Bank activities for the members of the DF/BWCC.

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