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Partners Online Second Opinions

For those with complex medical questions or concerns, looking for answers or alternatives, or simply peace of mind – we are here to help.

Partners Online Second Opinions has provided thousands of patients and physicians remote access to the many specialists affiliated with Partners HealthCare, a Harvard Medical School-affiliated healthcare delivery system, based in Boston, Massachusetts.

The Partners HealthCare network includes top hospitals in the United States, including Massachusetts General Hospital, Brigham and Women’s Hospital, Dana Farber Cancer Institute, and Spaulding Rehabilitation Hospital. Many of our specialists are world-renowned experts in their field, and are available to review medical history and related materials, and provide you with a written consultation report.

When you are faced with decisions regarding a new diagnosis or treatment plan, having another expert opinion is the first step towards getting the care you need.

For 200 years, patients have been traveling to Boston to get some of the best care in the world. Now you can access this expertise from the comfort of your home.


Featured Specialist
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Frances Hayes, MD


Dr. Hayes is a staff endocrinologist in Reproductive Endocrine Associates at the Massachusetts General Hospital, an Assistant Professor of Medicine at Harvard Medical School, Clinical Director of the Reproductive Endocrine Unit Reference Laboratory, and the principal investigator on a NIH funded Patient-Oriented Career Development Award. Dr. Hayes’ area of expertise is human reproductive physiology, a topic on which she has published widely. Her research interests include the neuroendocrine regulation of fertility in men, specifically the interplay between gonadotropin-releasing hormone, sex steroids, and non-steroidal factors in the regulation of FSH secretion. These studies have disclosed a previously unrecognized hypothalamic site of action of estradiol in men and provide evidence that estradiol rather than testosterone is the major sex steroid regulator of FSH secretion in men. In addition, she has demonstrated that inhibin B is more important than sex steroids in the control of FSH secretion in men. Her present research explores the relationship between testosterone and insulin resistance in men. To date, her studies have shown that insulin resistance in men is associated with a decrease in testicular Leydig cell secretion of testosterone. She is currently examining the impact of short-term medical castration on insulin sensitivity in normal healthy men as well as the impact of testosterone supplementation in men with the metabolic syndrome. Given the significant cardiovascular morbidity and mortality associated with obesity and type 2 diabetes, a clearer understanding of the interplay between testosterone and insulin resistance has important public health implications and may facilitate the development of new therapeutic strategies for these very common metabolic disorders. Her clinical practice covers the spectrum of reproductive endocrinology including polycystic ovary syndrome, infertility, and male and female hormone replacement therapy for hypogonadism. She coordinates the NIH-sponsored program of long-term pulsatile GnRH administration for men with congenital GnRH deficiency, a therapy that is currently limited to a few academic centers in the United States. In addition, she has expertise in ovulation induction with clomiphene, gonadotropins and pulsatile GnRH for women with idiopathic or anovulatory infertility.

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